Casablanca Valley is a wine-growing region of Chile, located 100 kilometers (60 miles) north-west of the country's capital, Santiago. The east-west-oriented valley is roughly 30km (20 miles) long, stretching to the eastern border of the Valparaiso province. It is best known for its crisp white wines, most notably made from the Sauvignon Blanc and Chardonnay grape varieties which have gained it recognition as one of Chile's quality wine regions. It has attracted considerable investment from wine companies based in other Chilean regions who were looking to boost their white wine portfolio, and from abroad. Pinot Noir, which is responsive to the cooler climates found in this coastal area, is also grown with some success.

The region is relatively new by Chilean standards. Casablanca Valley's first vineyards were planted in the 1980s during the revitalization of the Chilean wine industry. Expansion of vineyards around the industrial town of Casablanca followed, and vines now dominate the valley's landscape, even if a lack of water for irrigation (and restrictive local laws relating to this) have delayed vineyard planting.